New developments in treating gram-negative infections

Gram-negative bacteria comprise most of the CDC and WHO’s lists of critical and urgent antibiotic-resistant organism threats.
The problem of gram-negative resistance was exacerbated by the COVID-19 pandemic, according to a special report published by the CDC in 2022, which showed increasing rates of infections caused by carbapenem-resistant Acinetobacter (CRAB), carbapenem-resistant Enterobacterales (CRE), extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) from 2019 to 2020.
These increases reversed a trend of

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