New immune system-targeting compound shows early promise in treating lupus

Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn’s disease. This protein, known as SLC15A4, has been considered largely “undruggable,” as most researchers have long struggled to isolate the protein, determine its structure, or even pin down its exact function within immune cells—until now.

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