Patients with greater alpha-gal IgE levels report higher rates of knee pain, stiffness

Among patients with Ehrlichia IgG, Rickettsia IgG or alpha-gal IgE following a tick bite, only those with heightened levels of alpha-gal IgE demonstrated musculoskeletal symptoms, specifically higher rates of knee pain, according to data.
“While Lyme disease accounts for the majority of reported [tick-borne disease (TBD)] cases, spotted fever group rickettsiosis and ehrlichiosis remain important public health issues, particularly in southeastern states,” Diana L. Zychowski, MD, MPH, of the University of North Carolina at Chapel Hill, and colleagues wrote in JAMA Network Open. “For

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