Scientists find variant in the synaptonemal complex protein SYCE2 increases risk of pregnancy loss

While it is well established that chromosomal abnormalities are a major cause of miscarriages the biology behind pregnancy losses with or without chromosomal errors is not well understood. Over 114 thousand women from Iceland, Denmark, UK, U.S. and Finland who have experienced pregnancy loss participated in a genome-wide association study, testing 50 million sequence variants. A low frequency missense variant in the SYCE2 gene was found to increase the risk of pregnancy loss by 22%.

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